Precision Medicine in Anesthesiology and Pain Medicine

Our research focuses on anesthesiologic pharmacology, more specifically on clinical drug trials and pharmacometric modelling of the clinical data. The cornerstones of our research are acute pain medicine and procedural sedation.

Currently, the primary fields of our research explore the possibility to reduce opioid use with adjuvants added to opioid therapy in postoperative setting. We aim to find out model informed dosing schemes for different patient populations using pharmacometric methods, and to establish covariate effects that can be used in the future to individualize drug therapy.

The ultimate goal of our research is to introduce precision medicine in anesthesia and analgesia to reduce the opioid use in acute pain medicine, and to discover biomarkers that can predict chronic pain development.

Recent publications:

Ashraf M, Uusalo P, Scheinin M, Saari TI. Population modelling of dexmedetomidine pharmacokinetics and hemodynamic effects after intravenous and subcutaneous administration, Clin Pharmacokin. 2020; Online ahead of print.
Li X, Frechen S, Moj D, Lehr T, Taubert M, Hsin C-H, Mikus G, Neuvonen PJ, Olkkola KT, Saari TI, Fuhr U. A Physiologically-Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions. Clin Pharmacokinet. 597:81–808, 2020.
Uusalo P, Guillaume S, Siren S, Manner T, Vilo S, Scheinin M, Saari TI. Pharmacokinetics and Sedative effects of Intranasal Dexmedetomidine in Ambulatory Pediatric Patients. Anesth Analg. 130:949-57, 2020.